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Oral vitamin K for excessively anticoagulated patients Thrombus, Volume 6, Number 4.
The use of oral anticoagulant therapy has significantly increased over the last decade, both for prophylaxis and treatment of venous thromboembolic disease and for atrial fibrillation. Even well controlled patients spend only 70% of the time in their therapeutic range1 and overanticoagulation is a common problem that significantly increases the patient’s risk of bleeding.2 There are many variables associated with an increased risk of bleeding, as shown in Table 1.
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