Thrombus

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Mechanical prostheses and anticoagulation
Thrombus, Volume 7, Number 1.

Although the first mechanical valve was implanted in the descending aorta for a patient with aortic regurgitation, orthoptic mechanical heart-valve replacement surgery became possible with the advent of cardiopulmonary bypass in the mid-1950s Harken was credited with the first aortic valve replacement (AVR) in 1960, and Starr with the first mitral valve replacement (MVR), also in 1960. Both used caged ball valves. Shortly after this, caged disc valves were developed. In its early stages thromboembolism was a common feature – reported at up to 4% per year – and warfarin was the chief anticoagulant.

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